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Katsuhiko Kamei

Position Professor
Research Projects Project to Link Basic Sciences and Clinical Medicine
Division Division of Clinical Research
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E-mail k.kamei[at]faculty.chiba-u.jp
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Specialities

Main topics of research

Main publications

  1. Hagiwara D, Watanabe A, Kamei K: Sensitisation of an Azole-Resistant Aspergillus fumigatus Strain containing the Cyp51A-Related Mutation by Deleting the SrbA Gene. Scientific Reports, 6:38833, 2016.
  2. Kohno S, Tamura K, Niki Y, Izumikawa K, Oka S, Ogawa K, Kadota J, Kamei K, Kanda Y, Kiuchi T, Shibuya K, Takakura S, Takata T, Takesue Y, Teruya K, Tokimatsu I, Fukuda T, Maesaki S, Makimura K, Mikamo H, Mitsutake K, Miyazaki Y, Mori M, Yasuoka A, Yano K, Yamanaka N, Yoshida M： Executive Summary of Japanese Domestic Guidelines for Management of Deep-seated Mycosis 2014. Med Mycol J 57(4): E117-E163, 2016.
  3. Ishiwada N, Takeshita K, Yaguchi T, Nagasawa K, Takeuchi N, Hishiki H, Watanabe A, Kamei K, Shimojo N: The First Case of Invasive Mixed-Mold Infections Due to Emericella nidulans var. echinulata and Rasamsonia piperina in a Patient with Chronic Granulomatous Disease. Mycopathologia 181(3-4): 305-9, 2016.
  4. Hagiwara D, Takahashi H, Fujimoto M, Sugawara M, Misawa Y, Gonoi T, Itoyama S, Watanabe A, Kamei K: Multi-azole resistant Aspergillus fumigatus harboring Cyp51A TR46/Y121F/T289A isolated in Japan. J Infect Chemother 22(8): 577-9, 2016.
  5. Kusuya Y, Sakai K, Kamei K, Takahashi H, Yaguchi T: Draft Genome Sequence of the Pathogenic Filamentous Fungus Aspergillus lentulus IFM 54703T. Genome Announc 4(1): e01568-15, 2016．
  6. Watanabe M, Hayama K, Fujita H, Yagoshi M, Yarita K, Kamei K, Terui T: A Case of Sporotrichosis Caused by Sporothrix globosa in Japan. Ann Dermatol 28(2): 251-2, 2016.
  7. Reichert-Lima F, Busso-Lopes AF, Lyra L, Peron IH, Taguchi H, Mikami Y, Kamei K, Moretti ML, Schreiber AZ: Evaluation of antifungal combination against Cryptococcus spp. Mycoses 59(9): 583-93, 2016.
  8. Hagiwara D, Takahashi H, Kusuya Y, Kawamoto S, Kamei K, Gonoi T: Comparative transcriptome analysis revealing dormant conidia and germination associated genes in Aspergillus species: an essential role for AtfA in conidial dormancy. BMC Genomics 17(1): 358, 2016.
  9. Nanno S, Nakane T, Okamura H, Nishimoto M, Koh H, Nakamae H, Ohsawa M, Yarita K, Kamei K, Hino M: Disseminated Hormographiella aspergillata infection with involvement of the lung, brain, and small intestine following allogeneic hematopoietic stem cell transplantation: case report and literature review. Transpl Infect Dis 18(4): 611-6, 2016.
  10. Hagiwara D, Watanabe A, Kamei K, Goldman GH: Epidemiological and Genomic Landscape of Azole Resistance Mechanisms in Aspergillus Fungi. Front Microbiol 7: 1382, 2016.
  11. Nakao M, Muramatsu H, Takahashi T, Niwa S, Kagawa Y, Kurokawa R, Sone K, Uozumi Y, Ohkusu M, Kamei K, Koga H: Cryptococcus gattii Genotype VGIIa Infection in an Immunocompetent Japanese Patient: A Case Report and Mini-review. Intern Med 55(20): 3021-3024, 2016.
  12. Toyotome T, Takahashi H, Kamei K: MEIS3 is repressed in A549 lung epithelial cells by deoxynivalenol and the repression contributes to the deleterious effect. J Toxicol Sci 41(1): 25-31, 2016.
  13. Muraosa Y, Toyotome T, Yahiro M, Watanabe A, Shikanai-Yasuda MA, Kamei K: Detection of Histoplasma capsulatum from clinical specimens by cycling probe-based real-time PCR and nested real-time PCR. Med Mycol, 54(4): 433-8, 2016.
  14. Fagnani R, Resende MR, Trabasso P, Mikami Y, Schreiber AZ, Lopes AF, Muraosa Y, Kamei K, Moretti ML: Mortality related to candidemia and risk factors associated with non-Candida albicans. Infect Dis (Lond) 47(12): 930-931, 2015.
  15. Asahina A, Kobayashi M, Nakano K, Saito I, Yarita K, Kamei K, Tokura Y: Deep Cutaneous Infection with Microsphaeropsis arundinis: Report of two Japanese Cases. Acta Derm Venereol 95(7): 855-857, 2015.
  16. Kawakami H, Inuzuka H, Hori N, Takahashi N, Ishida K, Mochizuki K, Ohkusu K, Muraosa Y, Watanabe A, Kamei K: Inhibitory effects of antimicrobial agents against Fusarium species. Med Mycol, 53(6): 603-11, 2015.
  17. Matsudate Y, Murao K, Urano Y, Yarita K, Kamei K, Takeichi H, Kubo Y: Primary cutaneous mucormycosis caused by Mucor irregularis in an immunocompetent patient. J Dermatol 42(3): 267-268, 2015.
  18. Segawa S, Nishimura M, Sogawa K, Tsuchida S, Murata S, Watanabe M, Matsushita K, Kamei K, Nomura F: Identification of Nocardia species using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Clinical Proteomics 12: 6, 2015.
  19. Takahashi-Nakaguchi A,Muraosa Y, Hagiwara D, Sakai K, Toyotome T, Watanabe A, Kawamoto S, Kamei K, Gonoi T, Takahashi H: Genome sequence comparison of Aspergillus fumigatus strains isolated from patients with pulmonary aspergilloma and chronic necrotizing pulmonary aspergillosis. Med Mycol, 53(4): 353-360, 2015.
  20. Tamiya H, Ochiai E, Kikuchi K, Yahiro M, Toyotome T, Watanabe A, Yaguchi T, Kamei K: Secondary metabolite profiles and antifungal drug susceptibility of Aspergillus fumigatus and closely related species, A. lentulus, A. udagawae, and A. viridinutans. J Infect Chemother 21(5): 385-391, 2015.
  21. Toyotome T, Watanabe A, Ochiai E, Kamei K: N-acetylated α-linked acidic dipeptidase is identified as an antigen of Histoplasma capsulatum. Biochem biophys res commun 485(3): 483-487, 2015.
  22. Trabasso P, Matsuzawa T, Fagnani R, Muraosa Y, Tominaga K, Resende MR, Kamei K, Mikami Y, Schreiber AZ, Moretti ML: Isolation and Drug Susceptibility of Candida parapsilosis Sensu Lato and other Species of C. parapsilosis Complex from Patients with Blood Stream Infections and Proposal of a Novel LAMP Identification Method for the Species. Mycopathologia 179(1-2):53-62, 2015.
  23. Ueno K, Kinjo Y, Okubo Y, Aki K, Urai M, Kaneko Y, Shimizu K, Wang DN, Okawara A, Nara T, Ohkouchi K, Mizuguchi Y, Kawamoto S, Kamei K, Ohno H, Niki Y, Shibuya K, Miyazaki Y: Dendritic cell-based immunization ameliorates pulmonary infection with highly virulent Cryptococcus gattii. Infect Immun, 83(4): 1577-1586, 2015.
  24. Yagi K, Ishii M, Namkoong H, Asami T, Fujiwara H, Nishimura T, Saito F, Kimizuka Y, Asakura T, Suzuki S, Kamo T, Gonoi T, Kamei K, Tasaka S, Betsuyaku T, Hasegawa N. Pulmonary nocardiosis caused by Nocardia cyriacigeorgica in patients with Mycobacterium avium complex lung disease: two case reports. BMC Infect Dis 14(1):684, 2014.
  25. Hagiwara D, Takahashi H, Watanabe A, Takahashi-Nakaguchi A, Kawamoto S, Kamei K, Gonoi T: Whole-Genome Comparison of Aspergillus fumigatus Strains Serially Isolated from Patients Infected with Aspergillosis. J Clin Microbiol 52(12): 4202-4209, 2014.
  26. Hagiwara D, Suzuki S, Kamei K, Gonoi T, Kawamoto S: The role of AtfA and HOG MAPK pathway in stress tolerance in conidia of Aspergillus fumigatus. Fungal Genet Biol 73: 138-149, 2014.
  27. Nishimori M, Takahashi T, Suzuki E, Kodaka T, Hiramoto N, Itoh K, Tsunemine H, Yarita K, Kamei K, Takegawa H, Takahashi T: Fatal fungemia with Scedosporium prolificans in a patient with acute myeloid leukemia. Med Mycol J 55(4): E63-E70, 2014.
  28. de Souza M, Matsuzawa T, Lyra L, Busso-Lopes AF, Gonoi T, Schreiber AZ, Kamei K, Moretti ML, Trabasso P: Fusarium napiforme systemic infection: case report with molecular characterization and antifungal susceptibility tests. Springerplus 3: 492, 2014.
  29. Kawamura I, Kamei K, Yarita K, Ohkusu M, Ito K, Tsukahara M, Honda M, Nakashima K, Akamatsu H, Kurai H: Cryptococcus gattii genotype VGIIb infection in Japan. Medical Mycol J 55(3): e51-e54, 2014.
  30. Joichi Y, Chijimatsu I, Yarita K, Kamei K, Miki M, Onodera M, Harada M, Yokozaki M, Kobayashi M, Ohge H: Detection of Mucor velutinosus in a Blood Culture After Autologous Peripheral Blood Stem Cell Transplantation: A pediatric Case Report. Med Mycol J 55(2): e43-e48, 2014.
  31. Kikuchi K, Watanabe A, Ito J, Oku Y, Wuren T, Taguchi H, Yarita K, Muraosa Y, Yahiro M, Yaguchi T, Kamei K: Antifungal susceptibility of Aspergillus fumigatus clinical isolates collected from various areas in Japan. J Infect Chemother 20(5): 336-338, 2014.
  32. Kogure Y, Nakamura F, Shinozaki-Ushiku A, Watanabe A, Kamei K, Yoshizato T, Nannya Y, Fukayama M, Mineo, Kurokawa M: Pulmonary mucormycosis with embolism: two autopsied cases of acute myeloid leukemia. IInt J Clin Exp Pathol 7(6): 3449-3453, 2014.
  33. Mukai Y, Nureki S, Hata M, Shigenaga T, Tokimatsu I, Miyazaki E, Kadota J, Yarita K, Kamei K: Exophiala dermatitidis pneumonia successfully treated with long-term itraconazole therapy. J Infect Chemother 20(7): 446-449, 2014.
  34. Muraosa Y, Schreiber AZ, Trabasso P, Matsuzawa T, Taguchi H, Moretti ML, Mikami Y, Kamei K: Development of cycling probe-based real-time PCR system to detect Fusarium species and Fusarium solani species complex (FSSC). Int J Med Microbiol 304(3-4): 505-511, 2014.
  35. Sakai K, Trabasso P, Moretti ML, Mikami Y, Kamei K, Gonoi T: Identification of fungal pathogens by visible microarray system in combination with isothermal gene amplification. Mycopathologia 178(1-2): 11-26, 2014．
  36. Wang DN, Toyotome T, Muraosa Y, Watanabe A, Wuren T, Bunsupa S, Aoyagi K, Yamazaki M, Takino M, Kamei K: GliA in Aspergillus fumigatus is required for its tolerance to gliotoxin and affects the amount of extracellular and intracellular gliotoxin. Med Mycol 52(5): 506-518, 2014.
  37. Wuren T, Toyotome T, Yamaguchi M, Takahashi-Nakaguchi A, Muraosa Y, Yahiro M, Wang DN, Watanabe A, Taguchi H, Kamei K: Effect of Serum Components on Biofilm Formation by Aspergillus fumigatus and Other Aspergillus Species. Jpn J Infect Dis 67(3): 172-179, 2014.
  38. Toyotome T, Satoh M, Yahiro M, Watanabe A, Nomura F, Kamei K: Glucoamylase is a major allergen of Schizophyllum commune. Clin Exp Allergy 44(3): 450-457, 2014.
  39. Furusawa H, Miyazaki Y, Sonoda S, Tsuchiya K, Yaguchi T, Kamei K, Inase N: Penicilliosis marneffei Complicated with Interstitial Pneumonia. Intern Med 53(4): 321-323, 2014.
  40. Kohno S, Izumikawa K, Yoshida M, Takesue Y, Oka S, Kamei K, Miyazaki Y, Yoshinari T, Kartsonis NA, Niki Y: A double-blind comparative study of the safety and efficacy of caspofungin versus micafungin in the treatment of candidiasis and aspergillosis. Eur J Clin Microbiol Infect Dis 32(3): 387-397, 2013.
  41. Okubo Y, Wakayama M, Ohno H, Yamamoto S, Tochigi N, Tanabe K, Kaneko Y, Yamagoe S, Umeyama T, Shinozaki M, Nemoto T, Nakayama H, Sasai D, Ishiwatari T, Shimodaira K, Yamamoto Y, Kamei K, Miyazaki Y, Shibuya K: Histopathological Study of Murine Pulmonary Cryptococcosis Induced by Cryptococcus gattii and Cryptococcus neoformans. Jpn J Infect Dis 66(3): 216-221, 2013.
  42. De Luca Ferrari M, Ribeiro Resende M, Sakai K, Muraosa Y, Lyra L, Gonoi T, Mikami Y, Tominaga K, Kamei K, Zaninelli Schreiber A, Trabasso P, Moretti ML: Visual analysis of DNA microarray data for accurate molecular identification of non-albicans Candida isolates from patients with candidemia episodes. J Clin Microbiol 51(11): 3826-3829, 2013.
  43. Hagiwara D, Takahashi-Nakaguchi A, Toyotome T, Yoshimi A, Abe K, Kamei K, Gonoi T, Kawamoto S: NikA/TcsC Histidine Kinase Is Involved in Conidiation, Hyphal Morphology, and Responses to Osmotic Stress and Antifungal Chemicals in Aspergillus fumigatus. PLOS ONE 8(12): e80881, 2013.
  44. Nakamura Y, Suzuki N, Nakajima Y, Utsumi Y, Murata O, Nagashima H, Saito H, Sasaki N, Fujimura I, Ogino Y, Kato K, Terayama Y, Miyamoto S, Yarita K, Kamei K, Nakadate T, Endo S, Shibuya K, Yamauchi K: Scedosporium aurantiacum brain abscess after near-drowning in a survivor of a tsunami in Japan. Respir Investig 51(4): 207-211, 2013.
  45. Mori T, Nakamura Y, Kato J, Sugita K, Murata M, Kamei K, Okamoto S: Fungemia due to Rhodotorula mucilaginosa after allogeneic hematopoietic stem cell transplantation. Transpl Infect Dis 14(1): 91-94, 2012.
  46. Toyotome T, Yamaguchi M, Iwasaki A, Watanabe A, Taguchi H, Qin L, Watanabe H, Kamei K: Fetuin A, a serum component, promotes growth and biofilm formation by Aspergillus fumigatus. Int J Med Microbiol 302(2): 108-116, 2012.
  47. Gyotoku H, Izumikawa K, Ikeda H, Takazono T, Morinaga Y, Nakamura S, Imamura Y, Nishino T, Miyazaki T, Kakeya H, Yamamoto Y, Yanagihara K, Yasuoka A, Yaguchi T, Ohno H, Miyzaki Y, Kamei K, Kanda T, Kohno S: A case of bronchial aspergillosis caused by Aspergillus udagawae and its mycological features. Med Mycol 50(6): 631-636, 2012.
  48. Yoshida K, Kurashima A, Kamei K, Oritsu M, Ando T, Yamamoto T, Niki Y: Efficacy and safety of short- and long-term treatment of itraconazole on chronic necrotizing pulmonary aspergillosis in multicenter study. J Infect Chemother 18(3): 378-385, 2012.
  49. Watanuki Z, Okada S, Chiba S, Kamei K, Suzuki Y, Yamada N: Increased prevalence of high anti-cladosporium antibody titers in interstitial lung diseases. Tohoku J Exp Med 226(4): 287-291, 2012.
  50. Shimodaira K, Okubo Y, Ochiai E, Nakayama H, Katano H, Wakayama M, Shinozaki M, Ishiwatari T, Sasai D, Tochigi N, Nemoto T, Saji T, Kamei K, Shibuya K: Gene expression analysis of a murine model with pulmonary vascular remodeling compared to end-stage IPAH lungs. Respir Res 13(1): 103, 2012.
  51. Ohkouchi S, Ebina M, Kamei K, Moriyama H, Tamai T, Shibuya R, Ichinose M, Nukiwa T: Fatal acute interstitial pneumonia in a worker making chips from wooden debris generated by the Great East Japan earthquake and tsunami. Respir Investig 50(4): 129-134, 2012.
  52. Hasejima N, Kamei K, Matsubayashi M, Kawabe R, Shimura C, Hijikata N, Oda T, Matsushima H：　The first case of bloodstream infection by Candida intermedia in Japan: the importance of molecular identification. J Infect Chemother 17(4): 555-558, 2011.
  53. Park BJ, Taguchi H, Kamei K, Matsuzawa T, Hyon SH, Park JC: In Vitro Antifungal Activity of Epigallocatechin 3-O-Gallate against Clinical Isolates of Dermatophytes. Yonsei Med J 52(3): 535-538, 2011.
  54. Nagayoshi M, Tada Y, West J, Ochiai E, Watanabe A, Toyotome T, Tanabe N, Takiguchi Y, Shigeta A, Yasuda T, Shibuya K, Kamei K, Tatsumi K: Inhalation of Stachybotrys chartarum Evokes Pulmonary Arterial Remodeling in Mice, Attenuated by Rho-Kinase Inhibitor. Mycopathologia 172(1): 5-15, 2011.
  55. Biancalana FS, Lyra L, Moretti ML, Kamei K, Schreiber AZ: Standardization of Hyphal Growth Inhibition Rate as a Means of Evaluating Microsporum spp. in vitro Susceptibility to Terbinafine, Griseofulvin, and Ciclopiroxolamine. Mycopathologia 172(4): 279-285, 2011.
  56. Takizawa K, Hashizume T, Kamei K: Occurrence and characteristics of group 1 introns found at three different positions within the 28S ribosomal RNA gene of the dematiaceous Phialophora verrucosa: phylogenetic and secondary structural implications. BMC Microbiol; 11:94, 2011.
  57. Nakamura Y, Utsumi Y, Suzuki N, Nakajima Y, Murata O, Sasaki N, Nitanai H, Nagashima H, Miyamoto S, Yaegashi J, Hatakeyama T, Shibano Y, Yarita K, Kamei K, Nakadate T, Endo S, Terayama Y, Yamauchi K: Multiple Scedosporium apiospermum abscesses in a woman survivor of a tsunami in northeastern Japan: a case report. J Med Case Reports 5(1): 526, 2011.
  58. Anzawa K, Mochizuki T, Nishibu A, Ishizaki H, Kamei K, Takahashi Y, Fujihiro M, Shinoda H:　Molecular Epidemiology of Trichophyton tonsurans Strains Isolated in Japan between 2006 and 2010 and Their Susceptibility to Oral Antimycotics. Jpn J Infect Dis 64(6): 458-462, 2011.
  59. Takayama A, Itano EN, Sano A, Ono MA, Kamei K: An atypical Paracoccidioides brasiliensis clinical isolate based on multiple gene analysis. Med Mycol 48(1): 64-72, 2010.
  60. Watanabe A, Matsumoto K, Igari H, Uesato M, Yoshida S, Nakamura Y, Morita K, Shibuya K, Matsubara H, Yoshino I, Kamei K: Comparison between concentrations of amphotericin B in infected lung lesion and in uninfected lung tissue in a patient treated with liposomal amphotericin B (AmBisome). Int J Infect Dis 14(3): e220-223, 2010.
  61. Yamazaki Y, Akashi R, Banno Y, Endo T, Ezura H, Fukami-Kobayashi K, Inaba K, Isa T, Kamei K, Kasai F, Kobayashi M, Kurata N, Kusaba M, Matuzawa T, Mitani S, Nakamura T, Nakamura Y, Nakatsuji N, Naruse K, Niki H, Nitasaka E, Obata Y, Okamoto H, Okuma M, Sato K, Serikawa T, Shiroishi T, Sugawara H, Urushibara H, Yamamoto M, Yaoita Y, Yoshiki A, Kohara Y: NBRP databases: databases of biological resources in Japan. Nucleic Acids Res 38(Database issue): D26-D32, 2010.
  62. Ohno H, Ogata Y, Suguro H, Yokota S, Watanabe A, Kamei K, Yamagoe S, Ishida-Okawara A, Kaneko Y, Horino A, Yamane K, Tsuji T, Nagata N, Hasegawa H, Arakawa Y, Sata T, Miyazaki Y: An outbreak of histoplasmosis among healthy young Japanese women after traveling to Southeast Asia. Intern Med 49(5): 491-5, 2010.
  63. Yarita K, Sano A, Samerpitak K, Kamei K, de Hoog GS, Nishimura K: Ochroconis calidifluminalis, a Sibling of the Neurotropic Pathogen O. gallopava, Isolated from Hot Spring. Mycopathologia 170(1): 21-30, 2010.
  64. Oarada M, Igarashi M, Tsuzuki T, Kamei K, Hirasaka K, Nikawa T, Miyazawa T, Nakagawa K, Gonoi T: Effects of a high-protein diet on host resistance to Paracoccidioides brasiliensis in mice. Biosci Biotechnol Biochem 74(3): 620-626, 2010.
  65. Ohji G, Kikuchi K, Inoue K, Imoto K, Yamamoto S, Hosokawa N, Kamei K, Iwata K: Progressive disseminated histoplasmosis in an immunocompetent patient as an underrecognized imported mycosis in Japan. J Infect Chemother 16(6): 443-445, 2010.
  66. Takahashi H, Ueda K, Itano EN, Yanagisawa M, Murata Y, Murata M, Yaguchi T, Murakami M, Kamei K, Inomata T, Miyahara H, Sano A, Uchida S: Candida albicans and C. tropicalis Isolates from the Expired Breathes of Captive Dolphins and Their Environments in an Aquarium. Vet Med Int 22: 349364, 2010.
  67. Shimizu K, Li HM, Virtudazo EV, Watanabe A, Kamei K, Yamaguchi M, Kawamoto S: Deletion of CnLIG4 DNA ligase gene in the fungal pathogen Cryptococcus neoformans elevates homologous recombination efficiency. Mycoscience 51(1): 28-33, 2010.