研究
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渡邉哲

職種 教授
所属プロジェクト 臨床感染症プロジェクト
研究部門 真菌症研究部門
分野 臨床感染症分野
TEL 043-226-2786
FAX
E-mail fewata[at]faculty.chiba-u.jp
プロフィール写真

専門分野

感染症学（とくに真菌感染症）、真菌学、呼吸器病学

研究テーマ

真菌感染機構、抗真菌薬耐性機構

所属学協会

日本内科学会、日本呼吸器学会、日本感染症学会、日本化学療法学会、日本医真 菌学会、日本細菌学会、日本臨床微生物学会、日本結核病学会、日本環境感染学会

主な発表論文、著書

    Researchmap

    1. Van Braeckel E, Page I, Davidsen J, Laursen C, Agarwal R, Alastruey-Izquierdo A, Barac A, Cadranel J, Chakrabarti A, Cornely O, Denning D, Flick H, Gangneux JP, Godet C, Hayashi Y, Hennequin C, Hoenigl M, Irfan M, Izumikawa K, Koh WJ, Kosmidis C. Lange C, Lamprecht B, Laurent F, Munteanu O, Oladele R, Patterson T, Watanabe A, Salzer H: Treatment outcome definitions in chronic pulmonary aspergillosis: a CPAnet consensus statement. Eur Respir J 59(6): 2102950, 2022
    2. Takamatsu A, Yaguchi T, Tagashira Y, Watanabe A, Honda H: Nocardiosis in Japan: a multicentric retrospective cohort study. Antimicrob Agents Chemother 66(2): e01890-21, 2022.
    3. Takeda K, Suzuki J, Watanabe A, Narumoto O, Kawashima M, Sasaki Y, Nagai H, kamei K, Matsui H: Non-fumigatus Aspergillus infection associated with a negative Aspergillus precipitin test in patients with chronic pulmonary aspergillosis. J Clin Microbiol 60(2): e0201821, 2022.
    4. Khalifa HO, Hubka V, Watanabe A, Nagi M, Miyazaki Y, Yaguchi T, Kamei K: Prevalence of Antifungal Resistance, Genetic Basis of Acquired Azole and Echinocandin Resistance, and Genotyping of Candid krusei recovered from an International Collection. Antimicrob Agents Chemother 66(2): e0185621, 2022.
    5. Takeda K, Suzuki J, Watanabe A, Sekiguchi R, Sano T, Narumoto O, Kawashima M, Fukami T, Sasaki Y, Tamura A, Nagai H, Matsui H, Kamei K: The accuracy and clinical impact of the morphological identification of Aspergillus species in the age of cryptic species: A single-centre study. Mycoses 65(2):164-170, 2022.
    6. Khalifa HO, Watanabe A, Kamei K: Azole and Echinocandin Resistance Mechanisms and Genotyping of Candida tropicalis in Japan: Cross-Boundary Dissemination and Animal-Human Transmission of C. tropicalis Infection. Clin Microbiol Infect 28(2): 302.e5-302.e8, 2022.
    7. Toh-E A, Ohkusu M, Ishiwada N, Watanabe A, Kamei K: Genetic system underlying responses of Cryptococcus neoformans to cadmium. Curr Genet 68(1): 125-141, 2022.
    8. Majima H, Arai T, Kusuya Y, Takahashi H, Watanabe A, Miyazaki Y, Kamei K: Genetic differences between Japan and other countries in cyp51A polymorphisms of Aspergillus fumigatus. Mycoses 64(11): 1354-1365, 2021.
    9. Arai, T, Umeyama, T, Majima, H, Inukai, T, Watanabe, A, Miyazaki, Y, Kamei, K: Hmg1 mutations in Aspergillus fumigatus and their contribution to triazole susceptibility. Med Mycol 59(10): 980-984, 2021.
    10. Hino Y, Watanabe A, Seki R, Tsukamoto S, Takeda Y, Sakaida E, Kamei K: A Reference Laboratory Surveillance on Fungal Isolates from Patients with Haematological Malignancy in Japan. J Fungi(Basel) 7(10): 806, 2021.
    11. Toyotome T, Onishi K, Sato M, Hagiwara D, Watanabe A, Takahashi H: Identification of novel mutations contributing to azole tolerance of Aspergillus fumigatus through in vitro exposure to tebuconazole. Antimicrob Agents Chemother 65(9): e0265720, 2021.
    12. Trabasso P, Matsuzawa T, Arai T, Hagiwara D, Mikami Y, Moretti ML, Watanabe A: Development and validation of LAMP primer sets for rapid identification of Aspergillus fumigatus carrying the cyp51A TR46 azole resistance gene. Sci Rep 11(1):17087, 2021.
    13. Martins AC, Psaltikidis EM, Lima TC, Fagnani R, Schreiber AZ, Conterno LO, Kamei K, Watanabe A, Trabasso P, Resende MR, Moretti ML: COVID-19 and invasive fungal coinfections: a case series at a Brazilian referral hospital. J Med Mycol 31(4): 101175, 2021.
    14. Takahashi H, Umemura M, Ninomiya A, Kusuya Y, Shimizu M, Urayama S, Watanabe A, Kamei K, Yaguchi T, Hagiwara D: Interspecies Genomic Variation and Transcriptional Activeness of Secondary Metabolism-Related Genes in Aspergillus Section Fumigati. Front Fungal Biol, April 2021.Volume 2, Article 656751.
    15. Zhao S, Ge W, Watanabe A, Fortwende JR, Gibbons JG: Genome-Wide Association for Itraconazole Sensitivity in Non-Resistant Clinical Isolates of Aspergillus fumigatus. Front Fungal Biol, January 2021, Volume 1, Article 617338.
    16. Khalifa HO, Arai T, Majima H, Watanabe A, Kamei K: Evaluation of Surveyor Nuclease for rapid identification of FKS genes mutations in Candida glabrata. J Infect Chemother 27(6): 834-839, 2021
    17. Takeda K, Suzuki J, Watanabe A, Arai, T, Koiwa T, Shinfuku K, Narumoto O, Kawashima M, Fukami T, Tamura A, Nagai H, Matsui H, Kamei K: High detection rate of azole-resistant Aspergillus fumigatus after treatment with azole antifungal drugs among patients with chronic pulmonary aspergillosis in a single hospital setting with low azole resistance. Med Mycol 59(4): 327-334, 2021.
    18. Nguyen PT, Toh-E A, Nguyen NH, Imanishi-Shimizu Y, Watanabe A, Kamei K, Shimizu K: Identification and characterization of a sulfite reductase gene and new insights regarding the sulfur-containing amino acid metabolism in the basidiomycetous yeast Cryptococcus neoformans. Curr Genet 67(1): 115-128, 2021.
    19. Khalifa HO, Majima H, Watanabe A, Kamei K: In Vitro Characterization of Twenty-One Antifungal Combinations against Echinocandin-Resistant and -Susceptible Candida glabrata. J Fungi(Basel) 7(2): 108, 2021.
    20. Izumikawa K, Kakeya H, Sakai F, Shibuya K, Sugita T, Takazono T, Takata T, Tashiro M, Teruya K, Nakamura S, Noguchi H, Hiruma M, Makimura K, Miyazaki T, Miyazaki Y, Yamagishi Y, Yoshida K, Watanabe A: Executive Summary of JSMM Clinical Practice Guidelines for Diagnosis and Treatment of Cryptococcosis 2019. Med Mycol J 61(4): 61-89, 2020.
    21. Khalifa HO, Arai T, Majima H, Watanabe A, Kamei K: Genetic Basis of Azole and Echinocandin Resistance in Clinical Candida glabrata in Japan. Antimicrob Agents Chemother 64(9): e00783-20, 2020.
    22. Hino Y, Muraosa Y, Oguchi M, Yahiro M, Yarita K, Watanabe A, Sakaida E, Yokote K, Kamei K: Drain outlets in patient rooms as sources for invasive fusariosis: an analysis of patients with haematological disorders. J Hosp Infect 105(3): 518-526, 2020.
    23. Takeda K, Suzuki J, Watanabe A, Matsuki M, Higa K, Inoue E, Akashi S, Shimada M, Kawashima M, Ohshima N, Fukami T, Masuda K, Yamane A, Tamura A, Nagai H, Matsui H, Tohma S, Kamei K: Species identification, antifungal susceptibility, and clinical feature association of Aspergillus section Nigri isolates from the lower respiratory tract. Med Mycol 58(3): 310-314, 2020.
    24. Arai T, Majima H, Watanabe A, Kamei K: A simple method to detect point mutations in Aspergillus fumigatus cyp51A gene using a Surveyor Nuclease assay. Antimicrob Agents Chemother 64(4): pii: e02271-19, 2020.
    25. Pontes L, Beraquet CA, Arai T, Pigolli G, Lyra L, Watanabe A, Moretti ML, Schreiber A: Aspergillus fumigatus clinical isolates carrying CYP51A TR34/L98H/S297T/F495I mutation detected after 4 years retrospective azole resistance screening test in Brazil. Antimicrob Agents Chemother 64(3): pii: e02059-19, 2020.
    26. Toyotome T, Arai T, Watanabe A, Kamei K: Detection of substitutions at 98th, 121st, and 289th amino acid residues in Cyp51A using cycling probes. Med Mycol J 61(1): 7-10, 2020.
    27. Chihara Y, Tanaka Y, Izumi M, Hagiwara D, Watanabe A, Takegawa K, Kamei K, Shibata N, Ohta K, Oka T: Biosynthesis of β-(1→5)-Galactofuranosyl Chains of Fungal-Type and O-Mannose-Type Galactomannans within the Invasive Pathogen Aspergillus fumigatus. mSphere 5(1): pii: e00770-19, 2020.

    Webサイト

    http://clinical-r.pf.chiba-u.jp/